PQQ (Pyrroloquinoline Quinone) is a B Vitamin-like enzyme cofactor that helps to protect mitochondria (the cell’s energy supply) from oxidative stress. PQQ promotes the creation of fresh energy-generating mitochondria within cells. Thus, PQQ can help to improve cellular energy production.
In this clinical trial, 17 adult male and female subjects with sleep and fatigue complaints were studied to evaluate the effectiveness of PQQ. They ingested 20 mg of PQQ daily for 8 weeks. Changes in stress, fatigue, quality of life measures and sleep were evaluated using various inventories and questionnaires.
PQQ Improved Sleep and Reduced Fatigue Complaints
Six measures of vigor, fatigue, tension-anxiety, depression, anger-hostility, and confusion were significantly improved following PQQ administration compared with scores for those measures before administration of PQQ. Measures for quality of life, appetite, sleep, obsession and pain, also improved significantly.
Also, morning cortisol levels were measured and significantly reduced by the end of the study. Lower cortisol levels indicates better sleep quality.
The researchers concluded:
“In conclusion, PQQ supplementation seems associated with improved sleep quality and duration. Mood also was improved by diminishing feelings of fatigue, and
improved appetite, sleep, pain, and obsession scores. These data indicate that PQQ can be regarded as a potentially useful dietary supplement as it may relate to improving fatigue.”