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5-HTP Effective in Therapy Resistant Depressed Patients

5-HTP effective in depressed patients
Study Title: "l-5-Hydroxytryptophan in depression: the first substitution therapy in psychiatry? The treatment of 99 out-patients with 'therapy-resistant' depressions."
Number of Participants: 99
Length of Study: 14+ days
Type of Study: Open Trial
Publication: Neuropsychobiology
Study Result: Significant improvement in patients suffering from long-standing depression, who were previously unresponsive to therapy

99 patients suffering from therapy-resistant depression, meaning they did not improve when previously taking anti-depressant drugs or electroconvulsive therapy, were given 5-HTP at an average of 200 mg per day combined with the peripheral decarboxylase inhibitor, carbidopa. Complete recovery was seen in 43 of 99 patients, and another 8 had significant improvement. 5-HTP was effective so quickly, restored normal mood so fully, and did so with minimal side effects, that it should be regarded as an excellent anti-depressant.

The researcher concluded:

“This treatment produced an astonishing recovery without side effects in some 50% of patients.”

Depression
5-HTP
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    5-HTP

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