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5-HTP Improves Depression in 67% of Patients

5-HTP improves depression
Study Title: "Clinical evaluation of 5-hydroxy-L-tryptophan as an antidepressant drug"
Number of Participants: 59
Length of Study: 3 Weeks
Type of Study: Double-blind
Publication: Folia Psychiatrica et Neurologica Japonica
Study Result: Majority of patients (67%) had improvement of depression symptoms while using 5-HTP

The effectiveness of 5-HTP as an antidepressant drug was studied with 59 patients with depressive symptoms using the Rating Scale for Depression. In this double-blind clinical study of 5-HTP treatment of depression, a daily dose of 150 – 300 mg of 5-HTP was administered for three weeks.

Favorable responses were observed in 40 patients (67.8%), of whom 13 patients were markedly improved. 80% of the improved patients experienced their effects within a week of the treatment. The main side effects of 5-hydroxy-L-tryptophan were gastrointestinal disturbances which were minimized by the simultaneous administration of metoclopramide or trihexyphenidyl.

“A daily dose of 150 – 300 mg of 5-HTP was administered for three weeks. Favorable responses were observed in 40 patients (67.8%), of whom 13 patients were markedly improved. 80% of the improved patients experienced their effects within a week of the treatment.”

Depression
5-HTP
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