Research By Nutrient

In some countries extracts of the plant Hypericum perforatum L. (popularly called St. John’s wort) are widely used for treating patients with depressive symptoms. To investigate whether extracts of hypericum are more effective than placebo ...
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Fourth grade primary school children were directed to brush their teeth after school lunch using a dentifrice containing 5 % synthetic hydroxyapatite. The study was carried out for 3 years in order to examine the ...
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Background. Many types of toothpastes contain substances that can remineralize initial enamel caries. This study aimed to assess the effect of nano-hydroxyapatite (NHA) on microhardness of artificially created carious lesions. Methods. In this in vitro study, NHA ...
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This study was conducted to determine if there were any advantages to a form of selenium derived from Baker’s Yeast known as SelenoExcell®. The study found that the yeast-derived selenium reduced prostate cancers incidence by ...
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Calcium MCHA is a bioavailable source of calcium with scientific support for bone and teeth health. 40 patients at risk of osteoporosis were studied to prevent the appearance or progression of osteoporosis: 32 patients were ...
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The positive effects of the treatment of cellulite with the Centella Asiatica Extract were confirmed in the following 4 clinical studies. Study 1 A double-blind trial, involving 35 patients evaluated the size of fat cells ...
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A double blind study was designed to determine the effects of folate mouthwash on established gingivitis in non-pregnant adults. 60 subjects who had greater than 20 teeth, visible gingival inflammation around greater than 6 teeth, ...
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Coenzyme Q10 has research suggesting benefits in gum disease. In this study, ten male patients with adult periodontitis participated and 30 periodontal pockets were selected for topical application of Coenzyme Q10 (CoQ10) to the periodontal ...
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There is emerging resereach on the probiotic bacteria and their role in preventing and improving autism symptoms. In this study, 30 autistic children from 5 to 9 years old were evaluated according to the Gastrointestinal ...
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In clinical research, L-carnosine has been found to enhance frontal lobe function and be protective of brain function. This study investigated 31 children with autistic spectrum disorders in an 8-week, double-blinded study. Children were assessed ...
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Patients with celiac disease may have diarrhea despite being on a gluten-free diet. In this controlled, cross-sectional study, supplemental pancreatic enzymes were administered to provide symptomatic benefit in celiac patients with chronic diarrhoea. 259 patients ...
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Many digestive complaints are a result of inadequate production of digestive enzymes, especially the pancreatic enzymes for digesting carbs, fats, and proteins. In this double-blind, crossover study, supplemental pancreatic enzymes were given to healthy volunteers ...
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Berberine has been accumulating research for its beneficial impact on metabolic syndrome, insulin sensitivity, and insulin secretion. In this randomized, double-blind, placebo-controlled clinical trial on 24 patients with a diagnosis of metabolic syndrome, berberine was ...
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Both test tube and human studies have shown Berberine’s effect on high blood sugar and high cholesterol. This study evaluated the efficacy and safety of berberine in the treatment of type 2 diabetic patients with ...
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This study examined the associations between folic acid and multivitamin supplements used by the mother before and during pregnancy and the risk of autism spectrum disorder in offspring. 45,300 Israeli children born between January 1, ...
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This systematic review of the current research was conducted to evaluate the benefits of multivitamin supplementation during pregnancy on maternal, fetal and infant health outcomes. 17 studies involving 137,791 women contributed data to the review ...
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This study’s aim was to determine the optimal DHA concentration in term formula for supporting brain development in infants. This was a double-masked, randomized, controlled, prospective trial. A total of 181 infants were enrolled at ...
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Studies have demonstrated associations between omega-3s, omega-6s, and body mass index. In this study, the levels of omega-3 in pregnancy were studied for their effect on weight retention after childbirth, which can contribute to long-term ...
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The mother’s level of omega-3 fatty acids, including DHA, may improve fetal neural development with lasting consequences for child development. In this study, it was explored whether maternal fatty acid levels in red blood cells, ...
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Omega-3 fatty acids are a promising treatment for postpartum depression because of evidence from clinical trials, the advantage in safety, and their anti-inflammatory and cognitive health effects. In this meta-analysis, omega-3 fatty acids, DHA, and ...
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Preeclampsia is a pregnancy disease characterized by high blood pressure and signs of damage to another organ system, most frequently the liver and kidneys.  Fish oil, rich in omega-3 polyunsaturated fatty acids, is known to ...
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Increasing research indicates that magnesium deficiency may decrease the severity of PMS complaints, like headaches and migraines. In this 4 month double-blind, placebo-controlled study, magnesium supplementation at a dose of 360 milligrams a day was ...
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Fish oil is rich in the omega-3 fatty acids, DHA and EPA, which have consistently shown benefits in clinical research for conditions like ADHD, depression, memory loss, cognitive decline, and Alzheimer’s.  DHA, in particular, showed ...
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Regular consumption of alcohol can cause nutritional deficiencies, a major cause of chronic disease.  Alcohol actually inhibits the absorption and function of important nutrients such as thiamin (vitamin B1), vitamin B12, folic acid, and zinc ...
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Many Americans do not consume a balanced diet with enough servings of whole grains, fruits, and vegetables. If you are not getting the proper nutrients in a balanced diet then research indicates multivitamins can supply ...
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Nearly 50% of older adults have insomnia, with difficulty in getting to sleep, early awakening, or feeling unrefreshed on waking. A double-blind randomized clinical trial was conducted in 46 elderly subjects, randomly allocated into the ...
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In this randomized clinical trial, probiotics in differing potencies were given to patients on antibiotic therapy. The severity of digestive side effects from the antibiotic – bloating, cramping, and diarrhea – were measured in the ...
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In a randomized, placebo-controlled trial, 136 women who supplemented with calcium and vitamin D experienced an additional bone density benefit when they added orthosilicic acid, known as Biosil, to their supplement program. According to the researchers: ...
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Treatment of Alzheimer’s disease (AD) is difficult due to ignorance of its pathogenesis. AD patients have defects in phagocytosis of amyloid-beta (1-42) (Abeta) in vitro by the innate immune cells, monocyte/macrophages and in clearance of ...
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Context: Stress is a state of mental or emotional strain or tension, which can lead to underperformance and adverse clinical conditions. Adaptogens are herbs that help in combating stress. Ayurvedic classical texts, animal studies and ...
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A double-blind, placebo-controlled study was conducted to evaluate the efficacy an ethanolic extract of Aswagandha (Withania somnifera), in patients with ICD-10 anxiety disorders. The sample comprised 39 subjects, of whom 20 received the drug and ...
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Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon was suggested to have an important function in the formation and maintenance of ...
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Melatonin is a hormone involved in sleep regulation. Melatonin is currently used for secondary sleep disorders supported by research evidence. A small amount of evidence and some controversial results have been obtained in some randomized ...
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STUDY OBJECTIVES: To investigate the efficacy of melatonin compared to placebo in improving sleep parameters in patients with primary sleep disorders. DESIGN: PubMed was searched for randomized, placebo-controlled trials examining the effects of melatonin for the treatment ...
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BACKGROUND: Cognitive impairment is a major problem in elderly, affecting quality of life. Pre-clinical studies show that MMFS-01, a synapse density enhancer, is effective at reversing cognitive decline in aging rodents. OBJECTIVE: Since brain atrophy ...
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INTRODUCTION: Respiratory tract infections are common, and these infections occur frequently in children, susceptible adults, and older persons. The risk for recurrences and complications relates not only to the presence of viruses but also to ...
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Echinacea is one of the most commonly used herbal products for immune support. Multiple studies indicated it is effective for the common cold. The following meta-analysis was done by The Lancet To evaluate the effect ...
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PURPOSE: Caffeine can be a powerful ergogenic aid for the performance of prolonged, submaximal exercise. Little evidence, however, supports an ergogenic effect of caffeine on intermittent-sprint performance. Hence, this study was conducted to examine the ...
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BACKGROUND: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions ...
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An investigation was made to find out the importance of gugulu (Commiphora mukul) in thyroid function of mice and to reveal the possible involvement of lipid peroxidation (LPO), if any. While no marked change in ...
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Aswagandha root has historical use in the treatment of underactive thyroid. In this study, ashwagandha root extract was administered for 20 days by gastric intubation of male mice. The thyroid hormones T3 and T4 increased ...
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<Tongkat Ali, also known as Eurycoma longifolia, has clinical support for increasing testosterone levels. To test Tongkat Ali benefits in men between the ages of 30 and 55 years old, a randomized, double-blind, placebo controlled, parallel group ...
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Tongkat Ali, also known as Eurycoma longifolia, is reputed to be ‘Malaysian ginseng‘. Tongkat Ali testosterone effects were first verified in animal studies. In human studies, there is data supporting its use for male sexual ...
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This study involved 80 subjects. They received either one gram twice daily of BioCell Collagen or a placebo for 70 days. The treatment group experienced a significant improvement. All primary endpoint were met for statistical ...
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This study was conducted to test the efficacy and safety of Citrulline for ED. Also studied was citrulline’s effect in improving erection hardness and sexual frequency in patients with mild erectile dysfunction (ED). In the ...
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PQQ (Pyrroloquinoline Quinone) is a B Vitamin-like enzyme cofactor that helps to protect mitochondria (the cell’s energy supply) from oxidative stress. PQQ promotes the creation of fresh energy-generating mitochondria within cells. Thus, PQQ can help ...
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  Pyrroloquinoline quinone (PQQ) influences energy-related metabolism and neurologic functions in animals. The mechanism of action involves interactions with cell signaling pathways and mitochondrial function. However, little is known about the response to PQQ in ...
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Silicon has been suggested to have a role in the formation of connective tissue and is present in hair. Biosil is a bioavailable form of silicon which has been found to reduce wrinkle depth, skin ...
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Chondroitin sulfate belongs to a family of compounds called glycosaminoglycans (GAGs). GAGs form the ground substance of connective tissue such as cartilage. Chondroitin for arthritis is often combined with glucosamine sulfate in nutritional products to ...
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Glucosamine for arthritis is currently the most popular nutritional approach for that health concern. Many double-blind studies have proven glucosamine produces better results for osteoarthritis than NSAIDs (aspirin, Celebrex, Ibuprofen, etc.) or acetaminophen. Glucosamine for ...
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Maca, a Peruvian plant, has research supporting its use for libido and sexual function improvement. In this double-blind, randomized pilot study, a low-dose (1.5 grams/day) and a high-dose (3.0 grams/day) maca for libido regimen were ...
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(Deglycyrrhizinated Licorice) DGL for ulcershas been studied and found to be clinically effective. In this study, 100 patients with benign gastric ulceration were treated in a single-blind, endoscopically controlled trial to assess the relative efficacy ...
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In both in vivo and in vitro studies, zinc carnosine has shown promise in maintaining gut health and preventing gastric injury to the stomach and small intestine. In this study, 10 volunteers administered the NSAID ...
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Beta-sitosterol is a plant-based sterol found in the diet. Beta-sitosterol for prostate conditions is a common medical strategy in Europe, especially for BPH. In a randomized, double-blind and placebo-controlled clinical trial, 130 mg of beta-sitosterol ...
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Saw Palmetto for prostate enlargement (BPH) is well-studied in the scientific literature One of the most common prescription drug treatments for prostate enlargement is Tamsulosin, tradename Flomax®. The goal of this study was to compare ...
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Maca for men is known for its aphrodisiac effects and is becoming a popular treatment for erectile dysfunction. In this double-blind clinical trial on 50 Caucasian men affected by mild erectile dysfunction, maca dry extract, ...
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Sixty-six patients suffering from symptoms of ulcer infection were randomly allocated to one of two regimens: one group received lansoprazole, amoxycillin, and clarithromycin for 7 days. The other group received the same regimen plus zinc ...
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In this summary of new research on glutathione’s ability to improve liver function, natural medicine expert, Michael Murray, ND, describes glutathione as “one of the most important compounds that every cell in your body produces” ...
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Silymarin, the active principle of the milk thistle herb, protects experimental animals against various liver-toxic substances. In this research post, silymarin was shown to be effective in fatty liver disease. To determine if silymarin extends ...
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In a 3 month study 36 patients diagnosed with non-alcholic fatty liver disease were divided into 2 groups to determine if silymarin benefits liver disease patients. The first group was given silymarin (an extract of ...
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Airway hyper-responsiveness is one of the main features of allergic asthma. Quercetin has been studied for it anti-inflammatory and anti-allergy effects. In this study, the focus was quercetin’s effects in experimental allergic asthma. This experiment ...
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In this study, nettle extract (Urtica dioica) showed inhibition of several key inflammatory events that cause the symptoms of seasonal allergies. The causes of allergic inflammation that nettle extract prevented are: Release of histamine Mast ...
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Seasonal Allergic rhinitis (SAR) is characterized by a runny nose, congestion, sneezing and sinus pressure. A clinical study was performed to demonstrate the efficacy of food supplement containing Quercetin, Perilla frutescens, and Vitamin D3. 23 ...
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In a scientific review of the research literature, researchers highlighted quercetin as an effective anti-allergy agent. Quercetin’s anti-allergic properties are characterized by stimulation of the immune system, inhibition of histamine release, decrease in pro-inflammatory cytokines, ...
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In this double-blind, placebo-controlled study, the effects of Butterbur extract were compared to fexofenadine (Allegra) for perennial nasal allergies. Sixteen patients were given either Butterbur extract for a week or fexofenadine in the cross-over study ...
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Patients who met the International Headache Society criteria for a migraine, were ages 18 to 65, and had at least two to six attacks per month over the preceding 3 months, were treated with Butterbur ...
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Subjects included 64 adults and 16 children/adolescents treated for two months with the extract, followed by two months during which the intake of the extract was optional. Concomitant asthma medication was permitted. The number, duration, ...
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In previous studies, two randomized and placebo-controlled trials with a total of 289 migraine patients have demonstrated the efficacy and safety of a special butterbur root extract in the reduction of migraine attacks in adults ...
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The active ingredient in horny goat weed, icariin, has been studied for its ability to increase testosterone levels. In this study, male rats were injected with a chemical that damaged the reproductive system and then ...
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Horny Goat Weed, also known as Epimedium, is of interest to researchers for its effect on testosterone synthesis and its ability to increase nitric oxide, the chemical that makes Viagra effective. In this study, researchers ...
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Emerging research indicates most of the hangover symptoms are caused by the inflammation that alcohol consumption causes. Much of the inflammation is caused by impurities found in the alcohol beverage and generated when the body ...
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In this double-blind, placebo-controlled study, 62 postmenopausal women were treated with either 40 mg. of an herbal extract of black cohosh known as CR BNO 1055, or 0.6 mg conjugated estrogen or a matching placebo ...
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In this randomized double-blind placebo-controlled study conducted on Chinese women with moderate to severe premenstrual syndrome, the effectiveness of Vitex extract (also known as Chasteberry) was judged by the daily scoring of four symptom factors: ...
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Previous studies have shown Vitex (also known as Chasteberry) extracts to be effective for irregular menstrual cycles, cyclical mastalgia and symptoms of premenstrual syndrome (PMS). But dose-effect relationship for the treatment of PMS has not ...
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In this randomized, placebo-controlled, clinical double-blind study, 66 women with infertility or missed menstrual cycles completed the evaluation of treatment with an extract of Chasteberry to determine the effects on conception and mensturatin. The outcome ...
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HRT (Hormone Replacement Therapy) is generally effective for hot flashes during menopause, but the concerns about increased cancer risk make HRT unacceptable to many women. Soy isoflavones have been used as a potential alternative for ...
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In a breakthrough for iron deficiency anemia patients, a new form of iron called Ferrochel®, which is iron bisglycinate, was studied against the standard iron preparation ferrous sulfate. Just 15 mg/day of Ferrochel was compared ...
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A major breakthrough in nutritional science has been enhanced absorption products to maximize the effects of certain nutrients. Greenselect® Phtyosome is decaffeinated green tea extract complexed with phospholipids to enhance the metabolic effects of green ...
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Dioxins have been detected at high concentrations in breast milk, raising concerns about disorders in nursing infants caused by breast milk. The researchers analyzed dioxin levels in breast milk and maternal blood samples from 35 ...
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The aim of this study was to investigate whether curcumin, dispersed with colloidal nano-particles, named Theracurmin would be more effective against Esophageal Andenocarcinomo (EAC) cells and to analyze if this new compound affects T cell ...
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There are more than 10,000 studies on Pubmed® researching the amazing benefits of turmeric’s star family of nutrients, curcumin and the curcuminoids. The main impediment to realizing the full benefits of curcumin has been its ...
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Cranberry extract has been studied for its antibacterial effect primarily in the lab. In this open label pilot study, 12 women with at least 6 UTIs in the previous 12 months took one capsule of ...
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D-Mannose is becoming a popular supplement along with cranberry extract to prevent urinary tract infections (UTIs). In this study, d-mannose was tested on 73 Escherichia coli strains from women who regularly experience UTIs. Of the ...
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Calcium D-Glucarate is known to enhance liver detoxification by stopping the recycling of toxic hormones and environmental toxins. In this animal study, the rats were treated with the known carcinogen 7,12-dimethylbenz[a]anthracene. They supplemented the rats ...
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In a randomized, double-blind, placebo-controlled trial, 1200 IU of Vitamin D was administered to schoolchildren to assess if it reduced the risk of influenza and asthma. There was a 42% reduced risk of influenza in ...
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In a 7 year baseline survey and subsequent 18 year follow-up, 8,678 women were studied to determine if multivitamin use reduced the risk of cardiovascular disease death. When multivitamins were used for more than 3 ...
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In a study of 14,641 male physicians, the use of multivitamins were followed for a randomized, double-blind, placebo-controlled trial. During a median follow-up of 11.2 years, there were 2669 men with confirmed cancer, including 1373 ...
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Coenzyme Q10 (CoQ10) is a well-researched nutrient in cardiovascular health. Supplementation has been shown in numerous studies to improve heart function in conditions like heart failure, angina, coronary artery disease, and high blood pressure. In ...
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In an analysis of 36 randomized trials, including 22 double-blind in design, supplementation with omega 3 fish oil reduced systolic blood pressure by 2.1 mm Hg and diastolic blood pressure by 1.6 mm Hg. The ...
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In the British Journal of Clinical Practice, garlic extract was studied in 40 patients with high cholesterol. The patients were given 900 mg garlic powder per day, equivalent to 2,700 mg of fresh garlic. During ...
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In this meta-analysis of 20 random controlled trials, garlic supplements were found to lower blood pressure in patients with high blood pressure (≥140/90 mm Hg) by an average of 8.7 mm Hg for systolic and ...
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Both sodium reduction and the DASH (Dietary Approaches to Stop Hypertension) diet, which is rich in fruits, vegetables, and low-fat dairy products, and low in saturated fat and cholesterol, lowered blood pressure. This study investigated ...
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Celery extract has been shown in animal studies to help prevent stroke, improve blood flow, and act to protect the brain and enhance energy production. In a human study of 30 patients with mild to ...
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In this large meta-analysis of 12 double-blind randomized controlled trials (RCTs) for non-vertebral fractures and 8 randomized controlled trials for hip fractures, it was found that 400+ IU/day of Vitamin D resulted in a 29% ...
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244 patients were given 180 micrograms of Vitamin K2, as menaquinone-7 (MK-7). They were followed for three years to determine the Bone Mineral Density of the lumbar spine, total hip, and femoral neck. It was ...
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Arterial stiffness is a term to describe calcification and biological aging of the artery, oftentimes due to high blood pressure. It is more commonly knows as atherosclerosis, or thickening of the arteries. In a study ...
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A follow-up study was done on 4807 patients who participated in the population-based Rotterdam study. These patients were followed from 1990-2000 and had no history of heart attack at the beginning of the study. In ...
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In a study done in two phases, white kidney bean extract from the plant Phaseolus vulgaris, was found to cause weight loss during a 12 week period and maintain the lost weight over the following ...
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Phaseolus vulgaris extract, also known as white kidney bean extract, or commercially as Phase 2 Carb Block, was studied for 30 days in 60 slightly overweight subjects. Carb Blockers promote weight loss by interfering with ...
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In a follow-up of the Atherosclerosis Risk in Communities (ARIC) Study, 264 patients were observed for an average of 12 years to evaluate the association of magnesium deficiency with risk of sudden cardiac death (SCD) ...
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In a systematic review of the scientific literature, Vitamin D was found to be protective against a wide range of health problems, including: Heart Disease Multiple Sclerosis Cancer Osteoporosis Autoimmune Disease Infectious Disease Bone Fractures ...
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In this review of the scientific literature for probiotics, the authors found numerous benefits to probiotic use, including: Improvement of Intestinal Health; Reduction of Cholesterol; Cancer Prevention; Prevention of Antibiotic-associated Diarrhea; Enhancement of the Immune ...
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Current dietary guidelines recommend adequate intake of magnesium (310-420 mg daily) in order to maintain health and lower the risk of cardiovascular disease. Recent evidence from animal and clinical studies suggest that magnesium may be ...
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Functional constipation is a prevalent, burdensome gastrointestinal disorder whose treatment remains challenging. Probiotics have been increasingly investigated in its management. In this study, probiotics significantly reduced whole gut transit time by 12.4 hours and increased ...
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Seventy-seven patients with elevated LDL cholesterol and triglycerides were randomly assigned to a control group receiving placebo, two groups receiving orally administered rosuvastatin, a group receiving Bergamot alone orally (1000 mg/daily) and a group receiving ...
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Eighty men and women with high cholesterol were given a Bergamot-derived extract for 6 months. There was a 20% reduction in LDL, the unhealthy fraction of cholesterol; there was also a 17% decrease in triglycerides ...
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In a pooled analysis of observational studies, those participants with the highest blood levels of Vitamin D (top 25%) had a 50% lower risk of breast cancer than those participants with blood levels in the ...
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Study participants (70,495) were members of a cohort study (the Vitamins and Lifestyle Study) who were residents of Washington State aged 50–76 years at the start of the study (2000–2002). Participants were followed for mortality ...
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The Landmark Dietary Supplement Study performed by researchers at the University of California, Berkeley studied 278 men and women who took multiple dietary supplements for at least 20 years and compared them to 778 people ...
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99 patients suffering from therapy-resistant depression, meaning they did not improve when previously taking anti-depressant drugs or electroconvulsive therapy, were given 5-HTP at an average of 200 mg per day combined with the peripheral decarboxylase ...
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In 1991, 5-HTP was compared to the SSRI fluvoxamine (Luvox) for effectiveness against depression. Fluvoxamine is comparable to other SSRIs, such as Prozac, Zoloft and Paxil. In the study, 36 patients received either 300 mg ...
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The effectiveness of 5-HTP as an antidepressant drug was studied with 59 patients with depressive symptoms using the Rating Scale for Depression. In this double-blind clinical study of 5-HTP treatment of depression, a daily dose ...
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Previous observations have shown that oral administration of 5-HTP without dietary prescriptions causes decreased appetite, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and ...
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30 male students were separated into three groups: 1) took magnesium supplement, but did not exercise, 2) took magnesium supplement and did exercise, and 3) exercised, but did not take magnesium supplement. Total and free ...
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Editor’s Note:NAC has been shown in numerous studies to be effective in reducing the toxicity and addictive power of various recreational substances, including cocaine, marijuana, and alcohol. N-Acetyl-Cysteine (NAC) was studied in male Wistar rats ...
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More bad news for those who want to believe moderate alcohol consumption is healthy. In a 30 year study, 550 men and women with an average age of 43 were evaluated through a questionnaire and ...
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An important measure of healthy heart function called Heart Rate Variability (HRV) was improved when 16 patients with heart failure were supplemented with 300 milligrams of magnesium citrate. These patients were found to have normal ...
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In a study of 155 overweight adults with elevated blood pressure and normal magnesium levels, 300 milligrams of magnesium oxide was found to lower blood pressure much more than placebo in those patients with high ...
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Eight-two people between the ages of 40 and 75 with diabetes and high blood pressure were given 450 mg of magnesium daily. Over 4 months, 79 people completed the study and experienced an average reduction ...
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